UPDATE 1-Scotland study shows COVID-19 vaccines cut risk of severe disease

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(Adds context, expert comment and updated link to study preprint)

By Reuters Staff

LONDON (Reuters) - Scotland's vaccination drive appears to be markedly reducing the risk of hospitalisation for COVID-19, suggesting that both the Pfizer-BioNtech and Oxford-AstraZeneca shots are highly effective in preventing severe infections, preliminary study findings showed on Monday.

Results of the study, which covered the entire Scottish population of 5.4 million people, showed that by the fourth week after the initial dose, the Pfizer and AstraZeneca vaccines were found to reduce the risk of hospitalisation by up to 85% and 94% respectively.

"These results are very encouraging and have given us great reasons to be optimistic for the future," said Aziz Sheikh, a professor at the University of Edinburgh's Usher Institute who co-led the study.

Sheikh cautioned at a media briefing that the results are preliminary data, yet to be peer-reviewed by independent scientists, but added: "I am very encouraged. We now have national evidence...that vaccination provides protection against COVID-19 hospitalisations."

He expected other countries using the same vaccines and similar roll-out strategies - such as England and Wales - would see a similar positive impact in reducing numbers being hospitalised.

Prime Minister Boris Johnson will on Monday announce how he will ease lockdown restrictions as cases decline, aided by one of the world's fastest vaccine roll-outs.

Independent experts welcomed the Scottish findings.

"The primary aim of all vaccination campaigns is to stop people getting seriously ill and save lives," said Arne Akbar, president of the British Society for Immunology. "This initial data ... is extremely promising."

Data for the vaccines' effect in Scotland was gathered between Dec. 8 and Feb. 15. Researchers said that during this period, 1.14 million vaccines were administered and 21% of Scotland's population had received a first dose.

Among those aged 80 years and over - one of the highest risk groups for COVID-19 - vaccination was associated with an 81% reduction in hospitalisation risk in the fourth week, when the results for both vaccines were combined.

The study, released ahead of peer review, was uploaded to the Preprints with The Lancet website (https://bit.ly/2ZEq6hk) on February 19, 2020.

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