News
In cooperation with Reuters News and Reuters Health, we are proud to provide you with our continuously updated news feed. We select news that applies to physicians in all the major clinical specialties, as well as on finance, science, technology, and other areas.
'Less is more' in updated VA/DoD lipid clinical guideline
By Reuters Staff NEW YORK (Reuters Health) - An updated clinical practice guideline for managing lipid levels from the U.S. Department of Veterans Affairs and Department of Defense (VA/DoD) recommends
Avelumab shows survival benefit against advanced urothelial cancer
By Reuters Staff (Reuters Health) - Adding avelumab to the best supportive care as maintenance therapy for advanced or metastatic urothelial cancer can significantly extend overall survival by 31% and
Relative age effect may skew ADHD diagnosis, treatment in young children
By Marilynn Larkin NEW YORK (Reuters Health) - In Finland, the youngest children in a classroom are more likely to receive medication for attention deficit hyperactivity disorder (ADHD) than their
U.S. Black women with breast cancer face delayed, longer-lasting treatment
By Lisa Rapaport (Reuters Health) - Black women diagnosed with breast cancer in the U.S. are more likely to experience delayed treatment initiation and prolonged treatment duration that white women, a
Smartphone app iCanQuit effective as smoking cessation aid
By Lisa Rapaport (Reuters Health) - A head-to-head clinical trial of two smoking cessation smartphone applications found that an app based on acceptance and commitment therapy (ACT) was more effective
Later receipt of gender-affirming care for youth linked to worse mental health
By Linda Carroll (Reuters Health) - Worse mental health may result when gender incongruent youth seek gender affirming care at an older age and a later stage of puberty, a new Canadian study suggests.
ERAS approach to cesarean delivery linked to less opioid use, length of stay, costs
By Marilynn Larkin NEW YORK (Reuters Health) - Using the evidence-based enhanced recovery after surgery (ERAS) program for cesarean delivery was associated with decreased opioid use, shorter length of
UPDATE 2-U.S. CDC takes down coronavirus airborne transmission guidance
(Adds comment from WHO official, background) By Reuters Staff (Reuters) - The U.S. Centers for Disease Control and Prevention (CDC) on Monday took down its guidance warning on possible airborne
UPDATE 1-CDC takes down warning on airborne spread
(Updates with current CDC guidance) By Reuters Staff (Reuters) - The U.S. Centers for Disease Control and Prevention (CDC) said on Monday it had posted guidance on possible transmission of the new
More than 150 nations join WHO-led global plan for COVID vaccines
By Stephanie Nebehay and Kate Kelland GENEVA/LONDON (Reuters) - A total of 156 countries have joined the global COVAX scheme intended to ensure fair distribution of supplies of future vaccines against
WHO says no change to COVID-19 transmission guidance after U.S. change
By Reuters Staff LONDON (Reuters) - The World Health Organization has not changed its policy on aerosol transmission of the coronavirus, an official said on Monday after U.S. health officials updated
UPDATE 1-More nurses allowed to leave as Philippines eases travel ban
(Recasts story originally published Sept. 17, adds reaction from nursing groups, workers) By Karen Lema MANILA (Reuters) - More than a thousand Philippine health workers will finally be allowed to
U.S. sets record with over 1 million coronavirus tests in a day
By Lisa Shumaker (Reuters) - The United States set a one-day record with over 1 million coronavirus diagnostic tests being performed, but the country needs 6 million to 10 million a day to bring
Royal Caribbean, Norwegian Cruise submit health protocols to CDC looking to set sail again
By Nivedita Balu and Helen Coster (Reuters) - Hoping to set sail again after a long halt due to the COVID-19 pandemic, Royal Caribbean Group and Norwegian Cruise Line Holdings Ltd said on Monday they
U.S. CDC says coronavirus could spread through air
By Reuters Staff (Reuters) - The U.S. Centers for Disease Control and Prevention has warned that COVID-19 could spread through airborne particles that can remain suspended in the air and travel beyond
Liquid biopsy might help detect, manage liver cancer in the future
By Will Boggs MD NEW YORK (Reuters Health) - Liquid biopsy could someday be useful for the early detection and clinical management of hepatocellular carcinoma (HCC), according to a new review.
Severe donor obesity does not worsen heart-transplant outcomes
By Reuters Staff NEW YORK (Reuters Health) - Transplantation of hearts from severely obese donors is not associated with worse post-transplant outcomes than when hearts from slimmer people are used,
Hydration guided by urine flow rate better for preventing contrast-associated acute kidney injury
By Will Boggs MD NEW YORK (Reuters Health) - Urine flow rate (UFR)-guided hydration using the RenalGuard system is better than left ventricular end-diastolic pressure (LVEDP)-guided hydration for
Epidemiologist named new Czech health minister as COVID-19 cases surge
By Jason Hovet PRAGUE (Reuters) - Czech Prime Minister Andrej Babis nominated a top epidemiologist to become health minister on Monday after the previous minister quit over a sharp rise in COVID-19
Bristol Myers' Opdivo with Exelixis drug cuts kidney cancer death risk -study
By Michael Erman NEW YORK (Reuters) - Bristol Myers Squibb Co's cancer immunotherapy Opdivo in combination with Exelixis Inc's Cabometyx reduced the risk of death by 40% in previously untreated
EXCLUSIVE-Study suggests dengue may provide some immunity against COVID-19
By Pedro Fonseca RIO DE JANEIRO (Reuters) - A new study that analyzed the coronavirus outbreak in Brazil has found a link between the spread of the virus and past outbreaks of dengue fever that
EU agency recommends AstraZeneca-Merck drug Lynparza for two cancers
By Aakash B and Pushkala Aripaka (Reuters) - The European Medicines Agency (EMA) has recommended approval for Lynparza in patients with a form of prostate cancer and as a first-line maintenance
Immunomedics drug Trodelvy extends survival in breast cancer patients
By Manojna Maddipatla (Reuters) - Immunomedics Inc's cancer drug Trodelvy, which received accelerated U.S. regulatory approval in April, extended survival time in previously treated patients with an
Amgen drug shrinks tumors in lung cancer patients with KRAS gene mutation -study
By Deena Beasley (Reuters) - An experimental Amgen Inc drug that targets a specific genetic mutation shrank tumors in 32% of advanced lung cancer patients and 7% of those with colon cancer, according
AstraZeneca says Tagrisso shown to slow lung cancer spreading to brain
By Reuters Staff FRANKFURT (Reuters) - AstraZeneca's top-selling drug Tagrisso has been shown to slow the spread of a certain type of lung cancer to the brain when diagnosed at an early stage, the
Aspirin tied to higher risk of advanced cancer diagnosis and mortality
By Lisa Rapaport (Reuters Health) - Older adults who take daily low-dose aspirin may be more likely than those who don't to be diagnosed with advanced cancers and to die from these malignancies, a
Geriatric co-management tied to lower mortality after cancer surgery
By Lisa Rapaport (Reuters Health) - Patients aged 75 and older who undergo cancer surgery have lower 90-day postoperative mortality when they receive geriatric co-management than when they don't, a
If you do not snooze you lose: sleep seen as essential for the brain
By Will Dunham WASHINGTON (Reuters) - Scientists are providing a fuller understanding of the essential role that sleep plays in brain health, identifying an abrupt transition at about 2.4 years of age
More U.S. youth with commercial insurance getting HPV vaccination
By Lisa Rapaport (Reuters Health) - While a growing number of U.S. children with commercial insurance are getting the human papillomavirus (HPV) vaccine, inoculation rates remain below target levels,
COVID-19 can mimic acute stoneless gallbladder attack
By Marilynn Larkin NEW YORK (Reuters Health) - Two case reports from Switzerland show that COVID-19 can mimic acalculous acute cholecystitis and is associated with SARS-CoV-2 in the gallbladder wall.
Most teens, parents, clinicians OK with gender identity screening during wellness visits - pilot study
By Linda Carroll (Reuters Health) - When questions about gender were added to the standard pre-visit questionnaire for adolescent wellness visits at a Northern California healthcare network, the
U.S. reverses COVID-19 testing guidance again: exposed without symptoms need tests
By Carl O'Donnell and Manas Mishra (Reuters) - The Trump administration reversed guidance Friday on COVID-19 testing for a second time, urging those exposed to people with the virus to get tested even
Drinking alcohol may raise risk of high blood pressure in adults with diabetes
By Carolyn Crist (Reuters Health) - Drinking eight or more alcoholic beverages in a week could increase the risk of hypertension in adults who have type 2 diabetes, researchers have found. And the
Just 6% of UK population has COVID-19 antibodies - government scientific advisers
By Reuters Staff LONDON (Reuters) - Scientific advisers told the British government earlier this month that just 6% of the United Kingdom's population had antibodies to COVID-19, according to minutes
High prevalence of SARS-CoV-2 antibodies in Massachusetts community
By Reuters Staff NEW YORK (Reuters Health) - Nearly a third of residents tested in one Massachusetts community were positive for anti-SARS-CoV-2 antibodies, researchers report. Antibody testing allows
Stereotactic radiosurgery appears to benefit both older and younger patients with brain metastases
By Will Boggs MD NEW YORK (Reuters Health) - Stereotactic radiosurgery (SRS) provides similar overall survival in patients older and younger than 75 years who have brain metastases from lung cancer,
Narrowband UVB for vitiligo linked to lower fracture risk
By Anne Harding NEW YORK (Reuters Health) - Vitiligo patients who receive long-term narrowband UVB phototherapy are at lower risk of major osteoporotic fractures, new research shows. "Systemic
Study suggests new targets for noninvasive brain stimulation to treat insomnia
By Scott Baltic NEW YORK (Reuters Health) - Three specific brain regions - the bilateral supplementary motor area (SMA), right dorsolateral prefrontal cortex (DLPFC), and left superior temporal gyrus
Blood pressure often normalizes in kids diagnosed with hypertension
By Will Boggs MD NEW YORK (Reuters Health) - More than half of children initially meeting criteria for hypertension or elevated blood pressure subsequently have normal blood pressure levels, but many
Listening to Mozart may calm the epileptic brain, meta-analysis confirms
By Megan Brooks NEW YORK (Reuters Health) - Listening to Mozart may help reduce the frequency of epileptic seizures, an updated meta-analysis confirms. The "highly consistent" results suggest that
Epiretinal membrane may cause patients to close one eye to see better
By David Douglas NEW YORK (Reuters Health) - Patients with epiretinal membranes often close one eye to improve vision and this may impact their quality of life, according to a new record review. "
UPDATE 1-EU regulator backs dexamethasone as COVID-19 treatment
(Recasts, adds details on drug, background) By Reuters Staff (Reuters) - Europe's healthcare regulator has endorsed using dexamethasone to treat COVID-19 patients with breathing difficulties, paving
Roche gets key European panel recommendation for liver cancer cocktail
By Reuters Staff ZURICH (Reuters) - Swiss drugmaker Roche on Friday got a positive recommendation from a key European panel for its immunotherapy Tecentriq mixed with Avastin against liver cancer,
Prosecutors open homicide case after hacker attack on German hospital
By Reuters Staff DUESSELDORF (Reuters) - German prosecutors opened a homicide investigation on Friday into the case of a patient who died after a hospital in the western city of Duesseldorf was unable
U.N. food chief urges Bezos, other billionaires to step up to help world's starving
By Reuters Staff UNITED NATIONS (Reuters) - U.N. food chief David Beasley called on the world's billionaires on Thursday to step up to help save some 30 million people he said are at risk of dying if
90-minute British DnaNudge COVID-19 test is accurate, Lancet study finds
By Reuters Staff LONDON (Reuters) - A British COVID-19 test known as DnaNudge that gives results in just over an hour and which requires no laboratory was accurate in almost all cases, an academic
U.S. CDC testing guidance was published against scientists' objections -NYT
By Reuters Staff (Reuters) - Guidance about novel coronavirus testing posted last month on the website of the U.S. Centers for Disease Control and Prevention (CDC) was not written by the agency's
Russia approves first COVID-19 prescription drug for sale in pharmacies
By Reuters Staff MOSCOW (Reuters) - Russia has approved R-Pharm's Coronavir treatment for outpatients with mild to moderate COVID-19 infections and the antiviral drug could be rolled out to pharmacies
EU watchdog paves way for dexamethasone use in COVID-19 treatment
By Reuters Staff (Reuters) - Europe's health regulator has endorsed using dexamethasone to treat severely ill COVID-19 patients with breathing difficulty, paving way for the steroidal medication to
Roche says its drugs reduce ventilator need for COVID-19 patients
By Reuters Staff ZURICH (Reuters) - Roche's Actermra/Roactemra drugs reduce the likelihood patients with COVID-19 related pneumonia need mechanical ventilation, the company said on Friday. Hospital
Cumulative adverse childhood experiences tied to reduced quality of life
By Lisa Rapaport (Reuters Health) - Children involved with Child Protective Services (CPS) due to physical abuse have multiple exposures to experiences associated with reduced health-related quality
Dilute povidone-iodine nasal antiseptic kills SARS-CoV-2 rapidly in vitro
By Linda Carroll (Reuters Health) - Within 15 seconds of contact, a povidone-iodine nasal antiseptic at concentrations as low as 0.5% inactivated SARS-CoV-2 in vitro, a new study found. Working with a
CTE linked to REM behavior disorder in which individuals act out dreams
By Linda Carroll (Reuters Health) - Chronic traumatic encephalopathy (CTE), the neurodegenerative disease associated with repeated jolts to the brain, may be linked to a REM disorder in which
SARS-CoV-2 RNA in plasma linked to COVID-19 ICU admission, death
By Marilynn Larkin NEW YORK (Reuters Health) - SARS-CoV-2 RNA in plasma was associated with intensive care unit (ICU) admission and mortality in a single-center study of patients hospitalized with
FOCUS-Pfizer vaccine trial bets on early win against coronavirus, documents show
By Marisa Taylor and Dan Levine (Reuters) - Pfizer Inc is betting that its coronavirus vaccine candidate will show clear evidence of effectiveness early in its clinical trial, according to the company
EXCLUSIVE-France won't buy vaccines through WHO's COVAX scheme - ministry source
By Matthias Blamont PARIS (Reuters) - France will provide funding for an initiative led by the World Health Organization to buy potential COVID-19 vaccines, but will not source shots through the
Latin American nations seek more time to join WHO vaccine plan
By Anthony Boadle BRASILIA (Reuters) - Several Latin American countries have informed the World Health Organization (WHO) they intend to request more time to sign up for its global COVID-19 vaccine
Multidrug resistance common in hospitalized adults with HIV in Malawi
By Reuters Staff NEW YORK (Reuters Health) - HIV-1 multidrug resistance is common and is associated with increased mortality among adults hospitalized with HIV infection in Malawi, according to a new
OSA linked to increased risk of vertebral fractures in women
By Anne Harding NEW YORK (Reuters Health) - Women with obstructive sleep apnea (OSA) are more likely to sustain vertebral fractures (VFs), but their risk of hip fracture (HF) is not significantly
Takeda-led COVID-19 plasma product to begin trial this month
By Rocky Swift TOKYO (Reuters) - An experimental COVID-19 therapy using blood plasma, developed by Japan's Takeda Pharmaceutical Co and its partners, is scheduled to begin a late-stage clinical trial
Silicon Valley startup Visby's portable COVID-19 test gets FDA approval
By Jane Lanhee Lee and Nathan Frandino SAN JOSE, Calif. (Reuters) - Silicon Valley medical equipment startup Visby Medical has received Emergency Use Authorization by the U.S. Food and Drug
Johnson & Johnson charged by New York with civil insurance fraud over opioid claims
By Jonathan Stempel NEW YORK (Reuters) - New York state filed civil charges on Thursday accusing Johnson & Johnson of insurance fraud for downplaying the risks of opioid painkillers, including to
Keep an eye out for orthostatic hypotension in patients with Parkinson's
By Will Boggs MD NEW YORK (Reuters Health) - Both transient and classic orthostatic hypotension are common in patients with Parkinson's disease (PD) and warrant attention to avoid falls, researchers
UPDATE 1-Moderna to seek limited emergency use of COVID-19 vaccine if data shows high efficacy
(Adds details from conference call on enrollment, FDA filing) By Julie Steenhuysen CHICAGO (Reuters) - If Moderna Inc's COVID-19 vaccine proves to be at least 70 percent effective, the company plans
Facebook says it will no longer show health groups in recommendations
By Elizabeth Culliford and Akanksha Rana (Reuters) - Facebook Inc will no longer show health groups in its recommendations, the social media giant announced on Thursday, saying it was crucial that
UPDATE 1-Burned out and abused: French COVID-19 testers strike over work conditions
(Adds health minister's remarks) By Reuters Staff PARIS (Reuters) - Hundreds of workers at COVID-19 laboratories in France went on strike on Thursday, a trade union said, angry over poor working
TAVR does not worsen chronic kidney disease
By David Douglas NEW YORK (Reuters Health) - Renal impairment may stay stable or even show improvement after transcatheter aortic-valve replacement (TAVR) in most patients with chronic kidney disease
Post-COVID-19 myocarditis common in collegiate athletes
By Will Boggs MD NEW YORK (Reuters Health) - About one in seven competitive college athletes has evidence of myocarditis following COVID-19, according to a cardiac magnetic resonance (CMR) imaging
Pneumothorax possible with COVID-19 infection
By Megan Brooks NEW YORK (Reuters Health) - About one in 100 patients hospitalized with COVID-19 develops pneumothorax, according to what is believed to be the largest case series to date. During the
Positive COVID-19 tests linked with restaurant dining
By Reuters Staff (Reuters) - Among adults tested for the coronavirus at 11 U.S. healthcare facilities in July, those who were infected were about twice as likely to have dined at a restaurant in the
Newly discovered coronavirus proteins may be immune triggers
By Reuters Staff (Reuters) - Scientists have discovered 23 previously unknown proteins made by the novel coronavirus, including four that might be triggering patients' immune system to act - or in
New minimally invasive treatment effective for benign prostatic obstruction
By Reuters Staff NEW YORK (Reuters Health) - Transperineal interstitial laser ablation (TPLA) offers another effective minimally invasive treatment for men with benign prostatic obstruction,
NIH launches trial of Rigel drug for severe COVID-19
By Deena Beasley (Reuters) - The U.S. National Institutes of Health on Thursday launched a clinical trial of fostamatinib, currently used to treat a blood platelet-destroying autoimmune disorder, in
FOCUS-U.S. plans for hundreds of millions of cheap, fast COVID-19 tests
By Carl O'Donnell (Reuters) - U.S. manufacturers are sharply increasing production of cheap, fast - but less accurate - COVID-19 tests, aiming for 100 million per month by year end that will enable
Britain's COVID-19 testing regime buckles with delays and capacity constraint
By Alistair Smout LONDON (Reuters) - A sharp deterioration in turnaround times and availability of COVID-19 tests in Britain saw the government admit there were challenges to its testing regime that
Hundreds of French COVID-19 testers strike over work conditions, says union
By Reuters Staff PARIS (Reuters) - Several hundred workers at COVID-19 testing laboratories across France walked out on Thursday in protest against poor working conditions, one of the country's
BioNTech buys German site from Novartis to boost vaccine output
By Ludwig Burger FRANKFURT (Reuters) - BioNTech is buying a production site for the COVID-19 vaccine it is developing with Pfizer, aiming to boost output by several hundred million doses next year,
Press Release: WHO says safety comes first as over 170 nations join COVID-19 vaccine plan
By John Geddie and Aradhana Aravindan SINGAPORE (Reuters) - The World Health Organisation said that more than 170 countries had joined its global plan to distribute vaccines fairly around the world,
Moderna would seek limited emergency use of COVID-19 vaccine based on early data
By Julie Steenhuysen CHICAGO (Reuters) - If Moderna Inc's COVID-19 vaccine proves to be at least 70 percent effective, the company plans to seek emergency authorization for its use in high-risk groups
One in 7 reported COVID-19 infections is among health workers - WHO
By Stephanie Nebehay GENEVA (Reuters) - One in seven cases of COVID-19 reported to the World Health Organization (WHO) is a health worker and in some countries that figure rises to one in three, the
Philippines considers relaxing travel ban for nurses
By Karen Lema MANILA (Reuters) - The Philippines is considering allowing more nurses and other medical professionals to leave for jobs abroad after banning them from travel so they can fight
COVID-19 may have different impact on wellbeing for older adults
By Lisa Rapaport (Reuters Health) - COVID-19 disruptions to daily life and physical health may not impact wellbeing for older adults as much as it does for younger individuals, a small study suggests.
PCI use rising in US and Japan, but patterns differ
By Marilynn Larkin NEW YORK (Reuters Health) - Percutaneous coronary intervention (PCI) rates have gone up in both the U.S. and Japan, but the increases reflect a rise in nonelective procedures in the
Convalescent plasma may be an option for life-threatening pediatric COVID-19
By Marilynn Larkin NEW YORK (Reuters Health) - A small case series suggests convalescent plasma (CP) may be safe and "possibly" effective in children with life-threatening SARS-CoV-2- associated acute
Unexpected weight loss may merit cancer screening for certain primary care patients
By Lisa Rapaport (Reuters Health) - While most primary care patients presenting with unexpected weight loss have less than a 2% chance of being diagnosed with cancer over the next six months, a new UK
UPDATE 1-U.S. health agency spokesman Caputo takes leave after Facebook rant
(Adds Caputo statement) By Reuters Staff (Reuters) - Michael Caputo, the top communications official at the U.S. Department of Health and Human Services (HHS), will take a two-month-long leave of
COVID-19 screening in public venues is unreliable
By Reuters Staff (Reuters) - COVID-19 screening tests used at airports, schools, and other public places are not particularly effective, a large analysis for The Cochrane Library shows. Researchers
Monthly belimumab infusions preserve kidney function in some lupus patients
By Reuters Staff (Reuters Health) - Intravenous belimumab combined with standard lupus therapy can help preserve kidney function in patients with active lupus nephritis and cut the odds of death or a
For COPD with nocturnal hypoxemia, nighttime oxygen has no survival benefit
By Gene Emery NEW YORK (Reuters Health) - Although long-term oxygen therapy helps people with chronic obstructive pulmonary disease and chronic severe daytime hypoxemia live longer, it does not appear
More young adults survive heart attacks than severe COVID-19
By Reuters Staff (Reuters) - Among COVID-19 patients treated at 419 U.S. hospitals from April through June, only about 5% were ages 18 to 34. But that group had "substantial rates of adverse outcomes,
Broad U.S. rollout of coronavirus vaccine could happen mid-2021 - CDC
By Manas Mishra and Carl O'Donnell (Reuters) - A COVID-19 vaccine could be broadly rolled out in the United states by the middle of next year or a little later, the head of the federal government's
Top U.S. health agency spokesman Caputo to go on leave of absence
By Reuters Staff (Reuters) - Michael Caputo, the top communications official at the U.S. Department of Health and Human Services (HHS), will take a two-month-long leave of absence, the agency said on
Novartis ties bond sale to malaria treatment access in sustainability push
By Yoruk Bahceli AMSTERDAM (Reuters) - Novartis raised 1.85 billion euros on Wednesday from the sale of a bond on which interest payments will rise if the drugmaker fails to expand access to medicines
Follow-up confirms apalutamide survival benefits in some men with prostate cancer
By Reuters Staff NEW YORK (Reuters Health) - Apalutamide markedly extends overall survival in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC), according to a final analysis
Congenital CMV tied to increased prevalence of microcephaly
By Will Boggs MD NEW YORK (Reuters Health) - Congenital cytomegalovirus (CMV) is associated with a markedly increased prevalence of microcephaly at birth, according to a database study. "Congenital
UPDATE 1-Lilly says antibody drug cuts COVID-19 hospitalization, may seek emergency use nod
(Adds Lilly comment, analyst comment) By Deena Beasley (Reuters) - Eli Lilly and Co said on Wednesday interim trial data showed its experimental monoclonal antibody treatment reduced the need for
Lessons learned from COVID frontline: A Paris hospital refines ICU treatment
By Noemie Olive PARIS (Reuters) - Doctor Alexandre Avenel has four COVID-19 patients in his intensive care ward, all with depleted blood oxygenation levels but none under intubation. That might not
Genetic abnormalities common in autism-spectrum disorder
By Will Boggs MD NEW YORK (Reuters Health) - About one in eight children diagnosed with autism-spectrum disorder (ASD) have pathogenic findings after genetic testing, according to a new study. "We
Obese MS patients with limited mobility face greatest risk from COVID-19
By Megan Brooks NEW YORK (Reuters Health) - Obese patients with MS and limited mobility need to maintain increased vigilance during the ongoing COVID-19 pandemic, say researchers from New York. In a
Trial confirms benefit of SLIT for dust mite allergy
By Reuters Staff NEW YORK (Reuters Health) - A sublingual tablet containing house dust mite (HDM) extract is effective for reducing allergic rhinitis symptoms (AR), a new phase-3 trial shows. Over 12
