In cooperation with Reuters News and Reuters Health, we are proud to provide you with our continuously updated news feed. We select news that applies to physicians in all the major clinical specialties, as well as on finance, science, technology, and other areas.

Systemic steroids unlikely to cause severe psoriasis flares

By Marilynn Larkin NEW YORK (Reuters Health) - Although dermatologists are taught to avoid systemic steroids because of psoriasis flare risk, the rates and severity of flaring are "very low,"

Transanal minimally invasive surgery an option for certain rectal cancer patients

By Marilynn Larkin NEW YORK (Reuters Health) - In carefully selected rectal cancer patients, transanal minimally invasive surgery (TAMIS) is an option when local excision (LE) will likely be curative,

River blindness may have stopped spreading in most of the Americas

By Rob Goodier NEW YORK (Reuters Health) - The spread of river blindness, or onchocerciasis, may have been halted in nearly two-thirds of the 34,000 people who remain at risk in the Americas, new

Plaque characteristics independently tied to cardiovascular events

By David Douglas NEW YORK (Reuters Health) - In addition to traditional cardiovascular risk factors, inclusion of plaque characteristics beyond thickness alone can enhance prediction of cardiovascular

Tumor biopsy screening can identify actionable molecular targets

By Will Boggs MD NEW YORK (Reuters Health) - Large-scale screening of tumor biopsy specimens from patients with refractory malignancies can identify molecular alterations susceptible to

New biomarker for breast-cancer outcomes

By Will Boggs MD NEW YORK (Reuters Health) - Researchers may have found a new biomarker for outcomes of locally advanced breast cancer treated with neoadjuvant chemotherapy. In a paper in JAMA Network

U.S. hospitalized COVID-19 patient number hits record 90,000 ahead of expected case surge

By Gabriella Borter NEW YORK (Reuters) - The number of COVID-19 patients being treated in hospitals across the United States reached 90,000 on Friday after nearly doubling in the last month, just as

3D printing with alginate "ink" produces full-size heart model

By Anne Harding NEW YORK (Reuters Health) - A full-size model of an adult human heart can be made with 3-D bioprinting using alginate, a seaweed-derived material, new findings show. "That allows us

Many die from snakebites despite the availability of antivenom

By Rob Goodier NEW YORK (Reuters Health) - Snakebites may have claimed nearly 65,000 lives globally last year and are accountable for 3 million years of life lost, placing them at the top of the list

SGLT2 inhibitors appear beneficial in advanced kidney disease, too

By Reuters Staff NEW YORK (Reuters Health) - A post-hoc subgroup analysis of the CREDENCE study found that treatment with canagliflozin slowed kidney-function decline in patients with advanced

Medulloblastoma relapse may be predictable, allowing more tailored treatment

By Reuters Staff NEW YORK (Reuters Health) - It may be possible to predict relapse in children with medulloblastoma, allowing more tailored treatment and potentially better outcomes, report

Neuroinflammation common in familial frontotemporal dementia

By Scott Baltic NEW YORK (Reuters Health) - Neuroinflammation appears to be a typical feature of the three most common monogenic forms of familial frontotemporal dementia (FTD), according to a new

Explainer-When and how will COVID-19 vaccines become available?

By Julie Steenhuysen and Carl O'Donnell NEW YORK (Reuters) - Pfizer Inc with partner BioNTech SE and Moderna Inc have released trial data showing their COVID-19 vaccines to be about 95% effective at

When and which COVID-19 vaccines are likely to be available in Asia

By Reuters Staff (Reuters) - Pfizer Inc with partner BioNTech SE, Moderna Inc and AstraZeneca Plc have released trial data this month showing their experimental vaccines are effective in preventing

B-cell lymphoma might respond to N-myristoyltransferase inhibition

By Reuters Staff NEW YORK (Reuters Health) - Targeting N-myristoylation might prove to be an effective treatment for B-cell lymphoma and other cancers, according to a preclinical study. Myristoylation

Many with vaping lung injury may have lingering symptoms

By Anne Harding NEW YORK (Reuters Health) - Most patients who develop e-cigarette, or vaping, product use-associated lung injury (EVALI) are young white males, and nearly all admit to using illegal

Higher rates of cancer-risk genes in people with congenital heart disease

By Will Boggs MD NEW YORK (Reuters Health) - People with congenital heart disease (CHD) have an increased frequency of damaging variants in cancer-risk genes, researchers report. "As more patients

Transcatheter valve replacement curbs tricuspid regurgitation in many

By David Douglas NEW YORK (Reuters Health) - Patients at high surgical risk with severe, symptomatic functional tricuspid regurgitation (TR) treated with a first-generation transcatheter

AstraZeneca CEO says co likely to run new global trial on COVID-19 vaccine - Bloomberg News

By Reuters Staff (Reuters) - AstraZeneca Plc is likely to run an additional global trial to assess the efficacy of its COVID-19 vaccine, according to the company's Chief Executive Pascal Soriot,

Smoking at night linked to insomnia, shorter sleep times

By Carolyn Crist NEW YORK (Reuters Health) - Smoking cigarettes at night shows a stronger link to poor sleep than does smoking at earlier times in the day, according to a new study. To help patients,

GI symptoms linked with more severe COVID-19

By Reuters Staff (Reuters) - Gastrointestinal (GI) symptoms are associated with more severe COVID-19 and worse outcomes, two research teams have reported, a reversal of earlier data that suggested the

Most Americans still lack COVID-19 antibodies

By Reuters Staff (Reuters) - As of September, the vast majority of U.S. residents still had not been exposed to the new coronavirus, antibody test results suggest. In all 50 states, the District of

REFILE-Immediate breast reconstruction feasible following neoadjuvant chemo

(Adds slug, with no changes to text.) By Will Boggs MD NEW YORK (Reuters Health) - Long-term oncologic outcomes following neoadjuvant chemotherapy for breast cancer are similar with immediate breast

Immediate breast reconstruction feasible following neoadjuvant chemo

By Will Boggs MD NEW YORK (Reuters Health) - Long-term oncologic outcomes following neoadjuvant chemotherapy for breast cancer are similar with immediate breast reconstruction and conventional

Berlin plans six vast COVID-19 vaccination centres handling 4,000 people a day

By Caroline Copley BERLIN (Reuters) - Berlin is racing to open six mass vaccination centres capable of handling up to 4,000 people per day by mid-December, the project coordinator told Reuters on

ANALYSIS-Questions over AstraZeneca's COVID-19 vaccine data risk delaying approval

By Kate Kelland LONDON (Reuters) - Days after grabbing headlines with its COVID-19 "vaccine for the world", AstraZeneca is facing tricky questions about its success rate that some experts say could

Ocular side effects possible with checkpoint inhibitors

By Will Boggs MD NEW YORK (Reuters Health) - People who use immune-checkpoint inhibitors have an increased risk of noninfectious uveitis and myasthenia gravis, according to a database study. Several

New normal metrics should be used to assess gastroesophageal reflux, researchers say

By Will Boggs MD NEW YORK (Reuters Health) - New normal values for esophageal impedance-pH metrics, adjusted for region and testing system, should be used to assess gastroesophageal reflux,

COVID-19 may hurt male fertility

By Reuters Staff (Reuters) - Evidence of testes damage from COVID-19 has been accumulating in a series of small autopsy studies, suggesting that the new coronavirus could have an impact on male

Tumor characteristics in 'exceptional responders' may point to therapies for others

By Linda Carroll (Reuters Health) - A molecular analysis of tumors from patients who had exceptionally good responses to cancer treatments has helped researchers identify potential targets for

Women doctors still less likely to be promoted in academic medical centers

By Gene Emery NEW YORK (Reuters Health) - Twenty years after a major study demonstrated that women who graduate from medical school are less likely to be promoted in academic medical centers, a new

Many Title X clinics in southern U.S. refer young women elsewhere for PrEP

By Lisa Rapaport (Reuters Health) - More than a third of Title X family planning clinics in the southern U.S. don't provide any services related to HIV pre-exposure prophylaxis (PrEP) care, a recent

'Reassuring' data on cancer risk in people with multiple sclerosis

By Megan Brooks NEW YORK (Reuters Health) - People with multiple sclerosis (MS) are at increased risk of developing bladder cancer but not breast or colorectal cancer, according to a large study from

Tyrosine kinase inhibitor discontinuation can improve CML outcomes

By Marilynn Larkin NEW YORK (Reuters Health) - In patients with chronic myeloid leukemia (CML), discontinuing tyrosine kinase inhibitor (TKI) therapy is safe and associated with better

UPDATE 1-EU seeks to bypass patents to boost drugs access in crises

(Adds pharmaceutical industry reaction, paragraph 7) By Francesco Guarascio BRUSSELS (Reuters) - The European Union is planning bold measures to boost its access to drugs, from sidestepping patent

New assay platform enhances detection of circulating breast cancer cells

By Marilynn Larkin NEW YORK (Reuters Health) - Detection of circulating tumor cells (CTCs) in a breast cancer model was improved by a novel assay platform that uses a dual-receptor recognition and

EXPLAINER-How will Canada's COVID-19 vaccine program work?

By Allison Martell TORONTO (Reuters) - Canada has ordered more COVID-19 vaccine doses per capita than any other country - at least 194 million and up to 414 million doses for its population of 38

WHO experts would like to go to Wuhan, China, to probe COVID-19 origin

By Stephanie Nebehay GENEVA (Reuters) - Researchers led by the World Health Organization would like to go back to a wholesale food market in Wuhan in China to follow up initial cases of COVID-19 which

Patients cured of HCV still at high liver-cancer risk

By David Douglas NEW YORK (Reuters Health) - The burden of hepatocellular carcinoma (HCC) appears likely to move from patients who currently have hepatitis C virus (HCV) infection to those who have

No-biopsy diagnosis of CD an option in 'carefully selected' adult patients

By Anne Harding NEW YORK (Reuters Health) - No-biopsy diagnosis of celiac disease (CD) is possible in both adults and children, although the sensitivity is low, new findings suggest. Across three

Disrupted conscious access linked to altered brain connectivity in psychosis

By Anne Harding NEW YORK (Reuters Health) - People with schizophrenia have a higher threshold for conscious perception, which correlates with altered cerebral connectivity, new findings show.

Dengue incidence down by three-fourths in Wolbachia-treated areas in Indonesia

By Rob Goodier NEW YORK (Reuters Health) - The incidence of dengue appears to have dropped by 77% in areas of Yogyakarta City, Indonesia, that were treated with Wolbachia-infected mosquito eggs in a

Functional near-infrared spectroscopy can objectively detect tinnitus

By Lisa Rapaport (Reuters Health) - Functional near-infrared spectroscopy can be paired with machine learning tools to effectively detect the presence and severity of tinnitus, a small study suggests.

Repeat blood cultures in kids with Staph aureus bacteremia often unnecessary

By Reuters Staff NEW YORK (Reuters Health) - In children with Staphylococcus aureus bacteremia (SAB), there is no need for additional blood cultures to document clearance of the infection after two

SPECIAL REPORT- To reopen or not to reopen: That is the fraught question for U.S. schools

By Kristina Cooke, Benjamin Lesser and M.B. Pell (Reuters) - After a two-week deluge of calls and messages from parents - and at least one death threat - the school board in Chandler, Arizona, called

HIV, TB tests fall in East Europe and Central Asia due to COVID-19

By Reuters Staff MOSCOW (Reuters) - Testing for HIV and tuberculosis has fallen in Eastern Europe and Central Asia during the coronavirus pandemic and could lead to higher mortality rates, a U.N.

Watchdog criticises poor planning that left UK without enough PPE as COVID-19 struck

By Andrew MacAskill LONDON (Reuters) - Britain's failure to stockpile key pieces of personal protective equipment (PPE) before the coronavirus pandemic left supplies dangerously low and forced the

Mutations not making coronavirus able to spread more rapidly -study

By Kate Kelland LONDON (Reuters) - The COVID-19-causing coronavirus is mutating as it spreads around the world in the pandemic, but none of the mutations currently documented appears to be making it

EU seeks to bypass patents to boost drugs access in crises

By Francesco Guarascio BRUSSELS (Reuters) - The European Union is planning bold measures to boost its access to drugs, from sidestepping patent rights in emergencies to offering incentives for

EXPLAINER-When and how will COVID-19 vaccines become available?

By Julie Steenhuysen and Carl O'Donnell NEW YORK (Reuters) - Pfizer Inc with partner BioNTech SE and Moderna Inc have released trial data showing their COVID-19 vaccines to be about 95% effective at

Plasma from recovered patients shows little benefit in those hospitalized with COVID-19 -study

By Vishwadha Chander (Reuters) - Using blood plasma from COVID-19 survivors to treat patients with severe pneumonia caused by the novel coronavirus showed little benefit, according to data released on

More children swallowed powerful magnets after federal ban blocked

By Linda Carroll (Reuters Health) - After a federal rule banning powerful rare-earth magnets was blocked by a judge, increasing numbers of children have been turning up in U.S. emergency rooms having

Doctors Without Borders to withdraw from Venezuela hospital due to restrictions

By Reuters Staff (Reuters)Medecins Sans Frontieres (MSF) will withdraw from a collaboration with a Venezuelan hospital to treat COVID-19 patients due to restrictions on specialists' ability to enter

When and why do diverticulitis patients need surgery?

By Marilynn Larkin NEW YORK (Reuters Health) - An update to the American Society of Colon and Rectal Surgeons (ASCRS) guideline on diverticular disease suggests that surgery may not be needed in many

Absolute measures of efficacy, harms still missing from most clinical trial reports

By Frederik Joelving NEW YORK (Reuters Health) - Absolute measures of efficacy and harms are usually missing from reports of clinical trials in high-impact medical journals, flying in the face of

Children with exercise-induced respiratory symptoms may get conflicting diagnoses

By Lisa Rapaport (Reuters Health) - Children referred to outpatient clinics for exercise-induced respiratory symptoms often get a diagnosis that differs from the one they received from their primary

Give the coronavirus app bonus benefits to increase downloads, German state says

By Reuters Staff BERLIN (Reuters) - Germany's coronavirus tracing app needs to be made more compelling for users by offering fast-track entry to venues and queue jumping for events, according to a

No added heart and lung benefit of high-dose flu vaccine

By Megan Brooks NEW YORK (Reuters Health) - High-dose influenza vaccine is not more effective than standard-dose influenza vaccine in reducing the risk of dying or being hospitalized for

'On fire with COVID': Officials plead with Americans to stay home

By Susan Heavey and Maria Caspani (Reuters) - State and federal officials pleaded with Americans to stay at home and redouble efforts to curtail the coronavirus pandemic on Tuesday, defending

U.S. officials plan to release 6.4 mln COVID-19 vaccine doses in first distribution

By Rebecca Spalding and Carl O'Donnell (Reuters) - U.S. officials said on Tuesday they plan to release 6.4 million COVID-19 vaccine doses nationwide in an initial distribution after the first one is

OxyContin maker Purdue Pharma pleads guilty to criminal charges

By Mike Spector NEW YORK (Reuters) - Purdue Pharma LP pleaded guilty to criminal charges over the handling of its addictive prescription painkiller OxyContin, capping a deal with federal prosecutors

SPECIAL REPORT-50,000 COVID-19 deaths and rising. How Britain failed to stop the second wave

By Reuters Staff By Andrew MacAskill, Stephen Grey, Ryan McNeill, Steve Stecklow, Tommy Wilkes and Andrew R.C. Marshall HALIFAX, England, Nov 24 (Reuters) - On the doorstep of a terraced house in

Malawi ready to produce cannabis for industrial and medicinal use

By Reuters Staff BLANTYRE (Reuters) - Malawi is ready to start commercial production and processing of cannabis for medicinal and industrial use, the southern African country's new Cannabis Regulatory

Amazon, pharma firms should help COVID-19 vaccine reach poorest - German minister

By Reuters Staff BERLIN (Reuters) - Companies that have benefitted from the coronavirus crisis, such as Amazon and drugmakers, should join wealthy countries in helping to fund access to vaccines for

TAVR may be best choice for valve replacement after mediastinal radiation

By David Douglas NEW YORK (Reuters Health) - In patients who have previously undergone mediastinal radiation and require aortic-valve replacement, transcatheter aortic-valve replacement (TAVR) appears

High glucose may make MRSA more virulent in diabetes patients

By Anne Harding NEW YORK (Reuters Health) - High glucose levels in the tissue and blood of people with diabetes may help make drug-resistant Staphylococcus aureus infections more aggressive, new mouse

Anti-seizure medication shows promise in ALS

By Megan Brooks NEW YORK (Reuters Health) - The antiepileptic ezogabine (also known as retigabine) decreases pathological motor-neuron hyperexcitability in patients with amyotrophic lateral sclerosis

Adults, kids have different risks for antidepressant AEs by CYP2C19 status

By Anne Harding NEW YORK (Reuters Health) - Children who are normal metabolizers (NMs) based on CYP2C19 genotype are more likely to have adverse events (AE) with sertraline than are poor metabolizers

UPDATE 1-Nursing homes will be first to get COVID-19 vaccine in Spain

(Adds quotes, reaction, details) By Emma Pinedo and Ingrid Melander MADRID (Reuters) - Elderly residents and staff in nursing homes will be the first to get vaccinated against the coronavirus in Spain

INSIGHT-Decades of work, and half a dose of fortune, drove Oxford vaccine success

By Alistair Smout, Kate Kelland and Ludwig Burger LONDON/FRANKFURT (Reuters) - It took Oxford University's brightest minds decades of work to give them the expertise to develop a COVID-19 vaccine. In

USPSTF endorses behavioral counseling for adults with CVD risk factors

By Lisa Rapaport (Reuters Health) - Adults with risk factors for cardiovascular disease like hypertension, dyslipidemia and metabolic syndrome should receive behavioral counseling to promote healthy

AstraZeneca must prove it won't profit from COVID-19 vaccine - MSF

By Reuters Staff BRUSSELS (Reuters) - AstraZeneca must provide reassurance that it will not profit from its potential COVID-19 vaccine, non-governmental organisation Medecins Sans Frontieres (MSF)

Top Glove warns on deliveries after virus outbreak shuts plants

By Liz Lee KUALA LUMPUR (Reuters) - Malaysia's Top Glove Corp expects deliveries to be delayed and sales to fall below its forecasts after thousands of positive COVID-19 tests among its workers forced

INSIGHT-'We're drowning': COVID cases flood hospitals in America's heartland

By Nick Brown (Reuters) - Dr. Drew Miller knew his patient had to be moved. The vital signs of the 30-year-old COVID-19 victim were crashing, and Kearny County Hospital in rural Lakin, Kansas, just

Swedish watchdog finds serious failures in COVID care at nursing homes

STOCKHOLM (Reuters) - Sweden's health watchdog said on Tuesday it had uncovered "serious shortcomings" in COVID-19 care for residents of nursing homes where thousands have died, increasing pressure on

Spain to vaccinate workers and residents at nursing homes first

By Reuters Staff MADRID (Reuters) - Elderly residents and health workers at nursing homes will be the first to get vaccinated against the coronavirus in Spain, Health Minister Salvador Illa said on

U.S. to begin distributing Regeneron's COVID-19 antibody therapy Tuesday

By Manojna Maddipatla and Carl O'Donnell (Reuters) - The U.S. government will start distributing Regeneron Pharmaceuticals Inc's newly authorized COVID-19 antibody combination on Tuesday, beginning

Oral contraceptives may curb severe asthma attacks in young women

By Linda Carroll (Reuters Health) - Premenopausal women with asthma who use oral contraception that contains estrogen may be less likely to experience severe exacerbations, a new study suggests. An

Miniature lungs, colons help test COVID-19 treatments

By Reuters Staff (Reuters) - Tiny organ-like structures grown in the laboratory to behave like human lungs and colons can be used to rapidly screen drugs and identify those with potential as COVID-19

Remote disease management program improves lipids, blood pressure

By Megan Brooks NEW YORK (Reuters Health) - A cardiovascular risk management program delivered remotely improves blood pressure and cholesterol levels, according to an interim report from the first

Anti-cytokine therapy normalizes ACE2 expression in IBD, may protect against COVID-19

By Marilynn Larkin NEW YORK (Reuters Health) - Anti-cytokine therapy curbs inflammatory bowel disease (IBD) symptoms by normalizing reduced or elevated angiotensin-converting enzyme 2 (ACE2) levels,

Activated B cells could hold key to early-stage autoimmunity in rheumatoid arthritis

By Marilynn Larkin NEW YORK (Reuters Health) - B cells that contain anticitrullinated protein antibodies (ACPAs), a major risk factor for rheumatoid arthritis (RA), are most active in early-stage

Dosing error turns into lucky punch for AstraZeneca and Oxford

By Ludwig Burger and Kate Kelland FRANKFURT/LONDON (Reuters) - A stroke of good fortune from a dosing error will pave the way for AstraZeneca and Oxford University to submit their COVID-19 vaccine for

Switch between JAK and TNF inhibitors safe, effective for rheumatoid arthritis

By Lisa Rapaport (Reuters Health) - Rheumatoid arthritis patients who experience little or no reduction in symptoms from either Janus kinase (JAK) or tumor necrosis factor (TNF) inhibitor may achieve

Vitamin D supplement improves asthma control in adults with deficiency

By Lisa Rapaport (Reuters Health) - Adults with asthma who also have vitamin D deficiency may achieve better asthma control when they take 25-hydroxycholecalciferol supplements, a clinical trial

U.S. infectious disease group backs Gilead's remdesivir for COVID-19 treatment

By Rebecca Spalding (Reuters) - The top U.S. infectious disease medical association said on Monday that Gilead Sciences Inc's antiviral drug remdesivir should be used for hospitalized COVID-19

Airline body IATA develops mobile apps for COVID-era travel

By Reuters Staff PARIS (Reuters) - Global aviation body IATA is developing a set of mobile apps to help passengers to navigate COVID-19 travel restrictions and securely share test and vaccine

EU plans easier access to generics in potential blow to big drugmakers

By Francesco Guarascio BRUSSELS (Reuters) - The European Commission wants to make it easier for patients to access cheaper, generic medicines, a draft EU document seen by Reuters shows, in a move that

Previous hormonal-contraceptive use can slow return to normal fertility

By Anne Harding NEW YORK (Reuters Health) - Women who are trying to conceive take longer to recover their normal fertility if they were previously using certain hormonal contraceptives, new research

At-home cancer screening could thrive after the pandemic

By Carolyn Crist NEW YORK (Reuters Health) - Cancer screenings have dropped across the board during the coronavirus pandemic, yet home screening for colorectal cancer decreased less than in-person

Complete hemodynamic profiling tied to lower mortality from cardiogenic shock

By Will Boggs MD NEW YORK (Reuters Health) - The use of pulmonary-artery catheters (PAC) for complete hemodynamic profiling is associated with lower in-hospital mortality in patients with cardiogenic

Bone-mineral density correlates with coronary-artery calcification score

By Reuters Staff NEW YORK (Reuters Health) - Both trabecular and cortical volumetric bone-mineral density (BMD) are associated with coronary-artery calcium score (CACS), but in different directions,

Britain on track for spring vaccine roll-out, Oxford researcher

By Alistair Smout and Natalie Thomas LONDON (Reuters) - Britain is on track to make COVID-19 vaccines widely available by next spring after the shot developed by Oxford University and AstraZeneca was

Europe's air quality can still be deadly despite progress, EEA says

By Kate Abnett BRUSSELS (Reuters) - Many European citizens are exposed to harmful and sometimes illegal levels of pollution despite progress to improve air quality in recent years, the European

U.S. prepares for first COVID-19 shots as another vaccine candidate emerges

By Daniel Trotta (Reuters) - U.S. officials expect to begin inoculating Americans against the novel coronavirus by mid-December as another global drug company on Monday unveiled promising trial

Spain to begin vaccination programme in January, Sanchez says

MADRID (Reuters) - Spain will begin a comprehensive coronavirus vaccination programme in January and expects to have covered a substantial part of the population within six months, Prime Minister

WHO COVID envoy fears third wave, calls Europe response 'incomplete'

By Reuters Staff ZURICH (Reuters) - A World Health Organization (WHO) special COVID-19 envoy predicted a third wave of the pandemic in Europe in early 2021, if governments repeat what he said was a

U.S. FDA grants emergency use authorization to Regeneron COVID-19 antibody given to Trump

By Reuters Staff (Reuters) - The U.S. Food and Drug Administration on Saturday issued emergency use authorization for Regeneron Pharmaceuticals Inc's COVID-19 antibody therapy, an experimental

AstraZeneca starts new COVID-19 prevention trials of antibody cocktail

By Kate Kelland LONDON (Reuters) - AstraZeneca started late-stage trials on Saturday of an experimental long-acting monoclonal antibody combination drug it hopes could be used as a prophylactic to

COVAX must start talks with COVID-19 vaccine makers - Merkel

By Reuters Staff FRANKFURT (Reuters) - German Chancellor Angela Merkel has urged COVAX, an initiative set up to provide COVID-19 vaccines to poorer countries, to start talks immediately with producers

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